DISEASES IN CONNECTIVE-TISSUE BODIES

1. The general concepts

2. Osteoarthritis

3. Catarakt

4. Arthritises

5. Ischemic disease

6. Osteoporosis

The REASONS of DISEASES FORMATION in CONNECTIVE-TISSUE BODIES

1. The general concepts

To diseases connecting-tissue organ refer all types of the diseases, in accordance with infringement of the proteoglycans syntheses. To he refer: arthritises; an osteoarthritises; an osteochondrosis; a bursitis and tendinitis; an osteoporosis; a cataract and many others.

The Typical particularity of these diseases is a sharp pains when moving or lifting to gravity (increases the load on connecting-tissue organ, but the substances responsible for elasticity and wetting of rubbing surfaces, is synthesized by organism it is not enough or abnormal).

Usually physicians do not install the reasons of the shaping of these diseases and fix the treatment, connected with blocking symptoms disease data. Since symptoms disease data different, that and are offered different ways of the therapy of the fact that reason all these diseases one - a biochemical infringement of the syntheses to connective tissue or liquids, moistenning rubbing parts of body.

Existing ways of the therapy

Creation rest is recommended for majority of these diseases for sick with using blocking pain-relieving medicinal preparation.

Under long current disease, bring about destruction connecting-tissue organ, - a change the part of struck organ on artificial or syntetic created.

This brings about physical inability of the patient, creation to him additional load on the other organs.

TRUE UNDERSTANDING of FORMATION of the GIVEN DISEASES

Particularity of the chemical composition connecting-tissue organ

The Connective tissue portioned on the whole organism, it is included cartilages, sinews, copula, matrix of bones, it is found in area of pelvis, ureters, urethra, it "lays under" skin, serves for fixing of the blood vessels; it also forms the base an intercellular connecting substance in parenchymatous organ, such, as liver, and in muscle. From connective tissue are formed: bicuspid valve heart, larynx, lens of the eye and many other important organs.

Executing enormous mechanical, supporting function, connective tissue presents itself celluar structure, which also provides the syntheses of high-molecular compounds - mucopolysaccharides, proteoglycans, which stand out in intercellular space for wetting rubed parts of our organism, as well as syntheses some not cellular structures (as follows of them be supported construction on the matrix base of the lens, indissoluble fibres and many other structures).

In tab. 1 are submitted types of collagen in the connective tissue and their some properties.

Table 1. - Types of collagens and their some properties

Thus, collagen of the connective tissue practically always contains a carbohydrate part. Exactly contents carbohydrate in protein molecule brings about their abilities to be rubber-band and not to decay under short overloading. At infringement of the syntheses ���������, for want of minor sugar in blood, occurs the loss to resilience of the collagen fibres.

Alongside with collagen, proteoglycans form the basic substance extracellular matrix of the connective tissue and can form before 30% from dry mass tissue. Unlike simple glycoproteins, which contain only before 10% carbohydrate (on mass), the proteoglycans can contain before 95% (and more) carbohydrate. Main classes of the proteoglycans and their distribution are brought in tabl. 2 in different organ of the organism.

Table 2. Classes of the proteoglycans and their distribution in bodies

+ indicate detection of the given polysaccharides in the given tissue. Absence of a mark not necessarily testifies to full absence of others polysaccharides.

The hyaluronic acid represents polysaccharide consisting, basically, from glucuronic acid and N-acetylglucosamine.

Chondroitin sulfates represent polysaccharides consisting from glucuronic acid and N-acetylgalactosaminsulfate, galactose and xylose.

Keratansulfates, alongside with galactose and N-acetylglucosaminsulfate, contain fucose, mannose and sialic acid.

Heparin consists from glucuronilsulfate and N-acetylglucosaminsulfate.

Thus, for syntheses of the keratan sulfates necessary presence at blood of the person such monosaccharides as mannose and fucose. In ditto time for syntheses of the chondroitinsulfate necessary presence xylose.

Reasons of the shaping the infringements of the syntheses connecting-tissue organ

In the absence of minor sugar in blood of the person - mannose, fucose, xylose and others occurs the infringement of the syntheses proteoglycans, mucopolysaccharides (instead of mannose and fucose is built in glucose) and are formed glycosilation connections. Glycosilation proteoglycans have other physico-chemical characteristic (the transparency, bounce and resilience). Glycosilation mucopolysaccharides have other characteristic to fluidity, envelopping and moistenning abilities. Many probably felt beside itself in the mouth that sometimes saliva stands out such a water, are easy formed dripped the salivas, in the mouth always humid. In ditto time sometimes saliva becomes viscous, sticky, in the mouth is felt dryness. The Second condition just and points that beside You have begun be formed broken glycosilation mucopolysaccharides. Usually given simptom refer to such diseases, as xerostomia, tooth decay etc.

At the same time, exactly the mucopolysaccharides provide reliable wetting rubed parts connecting-tissue organ and does not allow friction directly of the proteoglycans, being situated on surfaces of the organ directly. All we know that for oiling rubed details in car, are used different mineral and syntetic oils with that or other additive.

In our organism of these functions execute different mucopolysaccharides, which are synthesized by cells of our organism.

If in organism are synthesized normal mucopolysaccharides, possessing normal wettability, that does not occur the direct contact between rubed parts connecting-tissue organ.

At the same time if in Your organism are synthesized glycosilation mucopolysaccharides, possessing low moistenning ability then at friction occurs the direct contact of rubed parts and appear to pangs. Thereby, origin by cutting to pains of rubed details organ signalize the organism about that that there are serious infringements and necessary urgently to take measures on exclusion further of similar infringements. But if You, instead of removal of this infringement, begin to take the anaesthesiatizing facility, which suppress these signals, that processes of friction begin to touch and structure of rubed organ with sformation of a superficial layers destruction. Hereinafter this can bring and to full destruction of rubed organ.

Excuse me for inconvenience. Given page is found in rework.

E-mail: IPChepurnoy@yandex.ru

HOME

copyright (c) 2007 Ivan P. Chepurnoy. All right reserved